However there is limited literature describing CHEK2mutations and polyposis. Mutations in CHEK2 are associated with a variety of cancers, including CRC. Genetic testing is recommended in patients with a personal history of young onset CRC, significant family history of CRC, or high polyp burden, defined as having greater than 10 adenomas. Fifteen to twenty percent of colorectal cancer (CRC) is familial and genetic alterations are commonly encountered.
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